Myelination by oligodendrocytes isolated from 4–6-week-old rat central nervous system and transplanted into newborn shiverer brain
Identifieur interne : 000074 ( France/Analysis ); précédent : 000073; suivant : 000075Myelination by oligodendrocytes isolated from 4–6-week-old rat central nervous system and transplanted into newborn shiverer brain
Auteurs : C. Lubetzki [France] ; A. Gansmüller [France] ; F. Lachapelle [France] ; P. Lombrail [France] ; M. Gumpel [France]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1988.
English descriptors
- Teeft :
- Acute rejection, Adult oligodendrocytes, Astrocyte, Astrocytic, Astrocytic processes, Cell debris, Cell processes, Continuous basal lamina, Electron microscopy, Extensive myelination, Fetal calf serum, Graft, Grafted, Grafted cells, Gumpel, Host animals, Host brains, Host parenchyma, Implantation site, Indirect immunofluorescence, Lachapelle, Long distance migration, Mature oligodendrocytes, Medium oligodendrocytes, Monoclonal antibody, Mouse brain, Multiple sclerosis, Myelin, Myelin membranes, Myelin sheath, Myelination, Nervous system, Neurol, Neuron, Neuronal nuclei, Newborn mouse, Newborn shiverer brain, Normal myelin, Numerous astrocytic processes, Oligodendrocyte, Optic nerve, Pellet, Polyclonal antibody, Positive cells, Positive fibers, Positive myelin, Positive myelination, Positive patches, Progenitor, Progenitor ceils, Progenitor cells, Remyelination, Rostral thalamus, Same buffer, Schwann cells, Semithin section, Semithin sections, Shiverer, Shiverer brain, Shiverer mouse, Sodium phosphate buffer, Transplantation, Transplantation technique, Ultrastructural, Ultrastructural criteria, Ultrastructural observation, Ultrathin sections, White matter.
Abstract
Abstract: Oligodendrocytes isolated from 4–6-week-old rat brains were transplanted into newborn shiverer brains. Cells were identified as mature oligodendrocytes both by immunocytological and ultrastructural criteria. Normal myelin was detected using immunolocalisation (with an anti-MBP antiserum) and electron microscopy (presence of the major dense line). Patches of normal myelin (made by transplanted oligodendrocytes), widely spread throughout the host brains, were detected between 20 and 130 days after grafting. No sign of acute rejection was observed, but the graft became progressively delimited by astrocytic processes forming a continuous basal lamina.
Url:
DOI: 10.1016/0022-510X(88)90214-6
Affiliations:
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ISTEX:6A6C5A1389087425DAEAD551B38283B9218AEB73Le document en format XML
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Gumpel</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neurobiologie cellulaire, moléculaire et clinique, INSERM U. 134</wicri:regionArea><wicri:noRegion>INSERM U. 134</wicri:noRegion><wicri:noRegion>INSERM U. 134</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">88</biblScope><biblScope unit="issue">1–3</biblScope><biblScope unit="page" from="161">161</biblScope><biblScope unit="page" to="175">175</biblScope></imprint><idno type="ISSN">0022-510X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute rejection</term><term>Adult oligodendrocytes</term><term>Astrocyte</term><term>Astrocytic</term><term>Astrocytic processes</term><term>Cell debris</term><term>Cell processes</term><term>Continuous basal lamina</term><term>Electron microscopy</term><term>Extensive myelination</term><term>Fetal calf serum</term><term>Graft</term><term>Grafted</term><term>Grafted cells</term><term>Gumpel</term><term>Host animals</term><term>Host brains</term><term>Host parenchyma</term><term>Implantation site</term><term>Indirect immunofluorescence</term><term>Lachapelle</term><term>Long distance migration</term><term>Mature oligodendrocytes</term><term>Medium oligodendrocytes</term><term>Monoclonal antibody</term><term>Mouse brain</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin membranes</term><term>Myelin sheath</term><term>Myelination</term><term>Nervous system</term><term>Neurol</term><term>Neuron</term><term>Neuronal nuclei</term><term>Newborn mouse</term><term>Newborn shiverer brain</term><term>Normal myelin</term><term>Numerous astrocytic processes</term><term>Oligodendrocyte</term><term>Optic nerve</term><term>Pellet</term><term>Polyclonal antibody</term><term>Positive cells</term><term>Positive fibers</term><term>Positive myelin</term><term>Positive myelination</term><term>Positive patches</term><term>Progenitor</term><term>Progenitor ceils</term><term>Progenitor cells</term><term>Remyelination</term><term>Rostral thalamus</term><term>Same buffer</term><term>Schwann cells</term><term>Semithin section</term><term>Semithin sections</term><term>Shiverer</term><term>Shiverer brain</term><term>Shiverer mouse</term><term>Sodium phosphate buffer</term><term>Transplantation</term><term>Transplantation technique</term><term>Ultrastructural</term><term>Ultrastructural criteria</term><term>Ultrastructural observation</term><term>Ultrathin sections</term><term>White matter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Oligodendrocytes isolated from 4–6-week-old rat brains were transplanted into newborn shiverer brains. Cells were identified as mature oligodendrocytes both by immunocytological and ultrastructural criteria. Normal myelin was detected using immunolocalisation (with an anti-MBP antiserum) and electron microscopy (presence of the major dense line). Patches of normal myelin (made by transplanted oligodendrocytes), widely spread throughout the host brains, were detected between 20 and 130 days after grafting. No sign of acute rejection was observed, but the graft became progressively delimited by astrocytic processes forming a continuous basal lamina.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Lubetzki, C" sort="Lubetzki, C" uniqKey="Lubetzki C" first="C." last="Lubetzki">C. Lubetzki</name></noRegion><name sortKey="Gansmuller, A" sort="Gansmuller, A" uniqKey="Gansmuller A" first="A." last="Gansmüller">A. 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